EMR (Endoscopic Mucosal Resection):

This technique is used to remove certain superficial neoplasms of the lumenal GI tract, inclusive of the esophagus, stomach, duodenum/small bowel, and colorectum. Lesions include Barrett’s esophagus with dysplasia and intramucosal cancer, superficial esophageal squamous cell carcinoma , gastric adenomas or dysplasia in intestinal metaplasia, certain superficial subepithelial tumors including symptomatic or high risk hyperplastic and fibroid hyperplastic polyps and pancreatic rests, sporadic duodenal/small bowel adenomas and colorectal adenomas. This technique is also utilized for endoscopic ampullectomy for ampulla neoplasms/adenoma in conjunction with ERCP with the hope of preventing the patient from major surgery with Whipple’s operation oncer there is no evidence of invasive cancer.

Sometimes this technique is employed with a hybrid deep dissection technique, particularly for large lesions in difficult locations and associated with fibrosis.

Below are some case examples of endoscopic mucosal resection (EMR):

Case 1: Wide field EMR of giant sigmoid colon polyp

1-Wide field EMR of giant sigmoid TA

This is a case of a giant lumen filling hemi-circumferential lobular and bulbous 8 cms type 0-ls; 0-lla polyp. The lesion was removed by debulking and widefield piecemeal EMR requiring resection in retroflexion of the anal/proximal aspect of the lesion which was obscured behind a haustral fold. Lesion under white light inspection(upper left image). Final appearance after wide field EMR incorporating more than half of the circumference of this segment of mucosa ( forward view. upper right image, retroflexed view, lower left image). Piecemeal specimen retrieved (lower right image). No post-procedure complications. Final pathology reveals tubulovillous adenoma with foci of high-grade dysplasia and resection base includes submucosa.


Case 2: Wide field EMR of flat laterally spreading granular lesion

This is a case of a large 2.5 cm type 0-lla laterally spreading granular polyp in the proximal descending colon under high definition wight light and NBI (upper left and middle images); endoscopic appearance after during submucosal injection with a special premixed solution (upper right image). Cap-assisted piecemeal EMR  (bottom three images); appearance after complete wide field resection incorporating a few millimeters of normal lateral mucosa. There were no post-procedure complications and final pathology reveals tubular adenoma without any high-grade dysplasia.


Case 3: EMR of laterally spreading granular lesion in the cecum

This is a case of a 2 cms type 0-lla laterally spreading granular lesion type in the cecum, high definition white light and NBI (upper left, middle and right images), further characterization polyp and it’s margins appearance under high definition white light and NBI after submucosal injection and adequate lift with special pre-mixed submucosal injection solution (lower left and middle images) and endoscopic appearance after cap assisted piecemeal EMR (lower right image). In this case, the mucosal defect was not closed and non-bleeding exposed submucosal vessels in the thin layer were left intact without coagulation to minimize the risk of delayed bleeding and perforation. There were no immediate or delayed post-procedure complications of subsequent follow-up. Final pathology reveals tubulovillous adenoma with a small focus of high-grade dysplasia away from cauterized /resection margin.

Case 4: EMR of non-ampulla duodenal adenomas in a patient with FAP and prior ampulla adenoma s/p endoscopic ampullectomy.                                              

 This is a case of a male patient with Familial Adenomatous Polyposis and colon cancer, s/p total colectomy who has developed ampulla and non-ampulla adenomas. He is s/p prior ERCP and endoscopic ampullectomy. Noted with two 8 and 10 mm type 0-lla and      8 mm type 0-llb adenomas in the periampullary region. Sequential EMR performed followed by clip closure (submucosal injection lift upper and lower left images; en bloc ensnarement of lifted flat lesion upper middle image; post resection base upper right image; overlapping resection in two pieces of adjacent non contigious lesions lower middle images; clip closure of post EMR margins lower right image).Note prophylactic PD stent placed at ERCP for surveillance and biopsies of post ampullectomy site. No post-procedure complications after overnight observation and final pathology reveal tubular adenomas without high-grade dysplasia.                                                                                         


  Case 5: Endoscopic Ampullectomy and ERCP for large ampulla adenoma.

Female patient referred with mild obstructive jaundice and dilated bile duct who was noted with large ampulla lesion concerning for a malignancy and inability to find bile duct orifice at attempted ERCP by referring endoscopist.

Follow up endoscopy/EUS reveal a 2.5 cm ampullary adenoma with concerning surface pattern features but no intraductal extension or submucosal invasion. ERCP was performed and revealed no filling defects in CBD or PD. Endoscopic ampullectomy was performed en bloc successfully followed by biliary and pancreatic sphincterotomy and placement of a pigtail prophylactic pancreatic duct stent. The post-ampullectomy resection margins was further ablated with APC to address any residual microscopic ademoma. Final pathology reveal tubular adenoma with foci of hig grade dysplasia but no invasive cancer. Lateral margin was clear within 1.5 mm of cauterized margin on specimen.                                                      

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